Electroactive bio-based chiral tweezers: Attractive selectors for enantioselective voltammetry

• New tools for chiral voltammetry in ionic liquid media: molecular “tweezers” Tweezer chirality from isomannide/isosorbide cores derived pool arm design enables modulating redox properties and coordination modes Tweezers can be liquids or/and additives achiral Successful enantiodiscrimination CV tests with tweezer Ionic (ILs), either themselves (CILs) or modified small quantities of CILs related salts as additives, have been proposed an effective tool to achieve terms potential differences voltammetric electroanalysis, on account their high local order at the electrode | solution interphase. cases already explored range biobased (or additives) including terpenol bile acid building blocks, having stereocentres stereogenic elements, “inherently chiral” scaffolds based biheteroaromatic atropisomeric cores. A further attractive family compounds worthy is “tweezer” dications consisting a isomannide isosorbide core two cation arms which include heteroatoms aromatic systems, thus providing many elements selector/probe interactions. wide, systematic series such tweezers presented, characterized thermal features (by gravimetric analysis differential scanning calorimetry) stereochemical electronic circular dichroism spectroscopy), submitted exhaustive electrochemical study highlight rationalize properties. preliminary tests, performed employing rac -N-3,5-dinitrobenzoyl phenylglycine methyl ester (DNB-PhGly) well 2,2,2-trifluoro-1-(9-anthryl)ethanol (TFAE) electroactive probes combination selected tweezers, confirm attractiveness selectors enantioselective electroanalysis.